11 Best NMN Supplements Review [2023]: David Sinclair’s #1 NAD Booster

Scientists discovered a powerful anti-aging supplement called nicotinamide mononucleotide (NMN).

An anti-aging book called Lifespan brought widespread attention to this cellular health and longevity-boosting molecule.

By restoring proper energy balance to the body’s delicate systems, you slow the aging process.

Longevity expert David Sinclair has focused his career on nicotinamide mononucleotide.

You naturally get trace amounts through diet, but only supplements cause robust health effects. Unfortunately, some NMN supplements do more harm than good.

Use this review to learn about the scientific benefits and how to choose the best NMN supplement for your unique lifestyle.

To summarize…

The Best Nicotinamide Mononucleotide (NMN) Supplements of 2023

Strongest NMN – Powdered Liposomal NMN

Highest-Quality NMN – Pharmaceutical-Grade PUR™ 60B

Best Sublingual NMN – Renue By Science

Cheapest NMN – Pure NMN Powder

Stability Guaranteed – Do Not Age NMN

Best Bulk NMN (Private Label) – Ultra Health 30C

Best Value NMN – Nootropics Depot Enteric Coated Tablets

Original Liposomal NMN Elixir – QuickSilver Scientific

After reviewing the products, I’ll walk through everything you should know about nicotinamide mononucleotide.

Dangers of Most NMN Supplements

Recently, I cut severely back on my supplement intake. This is why.

Firstly, third-party reports regularly find high levels of supplement contamination. Heavy metals, impurities, and other banned substances lurk in innocent products.

Then there’s fraud. Some products don’t even contain ANY of the primary ingredients! Instead, they fill capsules with whatever cheap materials they can find.

Commercial NMN is relatively new. Researchers like Dr. Sinclair create a surge in demand, and manufacturers can’t match the supply. Stores have become littered with fake, adulterated, (and expensive) products.

2022 Update: Massive Fake NMN Supplement Scam

I’ve long warned about the lack of regulatory oversight of NMN products.

And it’s far worse than I thought.

In late February 2022, a shocking third-party investigation uncovered tens of thousands of fake supplements sold on Amazon. Many of these included NMN.

A few of the dozens of fake brands include:

• Komprocha
• NMN Max
• NMN Plus
• Energecko
• Vitablossom
• Mistacy
• ChriBubble
• Glorifikation

Many of which are the “best sellers” in their respective categories.

You can see the references and lab CoA data for yourself here.

Keep in mind that this is only one recent discovery. Likely just the tip of the iceberg.

Don’t fall victim to NMN scams.

On the other hand…

The brands I trust (listed below) have mostly either been directly used in clinical studies or undergone strict third-party testing.

Today, I regularly talk to the best-informed minds in longevity. This is my regularly updated list of the best nicotinamide mononucleotide products I’m coming across.

2023 Update: The NMN Ban

Beginning in November 2022, you may have heard the major NMN news. A legal battle instigated by a large biotech company caused the FDA to revoke NMN’s status as a dietary supplement.

For months, everything continued as normal.

Then Amazon warned β-nicotinamide mononucleotide vendors that they will yank their products from shelves on March 13th. All products that do not contain a National Drug Code (NDC) on the label. Amazon is full of fraudulent supplements, so I view this as a net positive. Hopefully, other regulators will not follow suit.

Certain vendors have assured me that, for legal reasons, their NMN supplements will be exempt from the potential ban.

Sellers that will continue legally selling NMN post-Amazon ban include:

• Renue by Science
• UltraHealth

If, however, regulatory agencies successfully NMN across the board, you still have other options. See this new post for a list of free habits and other great NMN alternatives that also increase NAD+.

Prefer video?

The Best NMN Supplements Brands & Products for Anti-Aging

Your ideal NMN product depends on your goals and budget:

• For most people, I recommend liposomal formulations which give you maximum absorption (as described later)
• For those looking to combat neurodegeneration and boost cognitive energy, I’d choose an intranasal spray
• For the budget-conscious, normal powders (used sublingually) are the best value

Before we get started…

Am I missing a product? Be sure to check the comments below where we’re having an ongoing discussion about other and new brands.

How NMN & NAD+ Work (Simple Explanation)

Nicotinamide mononucleotide builds a critical energy-generating molecule called NAD. You’d drop dead in 30-seconds without it. Every cell throughout the body relies on it. 500+ enzymes wouldn’t work without it. Vital roles of NAD include:

• Slowing aging by activating anti-aging proteins called sirtuins
• Increasing energy (Krebs Cycle)
• Repairing damaged DNA (PARP1)
• Creating hormones
• Facilitating muscle-building
• Enhancing recovery

Leading scientists get excited by things that bolster the body’s built-in defense mechanisms. Sirtuins do exactly that, but only if you have adequate NAD.

The natural aging process slowly degrades NAD. A 50-year-old has roughly half the levels of a 20-year-old. Though you’ll live with low NAD, you’ll accelerate the aging process and reduce your healthspan.

That’s where NMN helps.

NMN is a synthetically produced nucleotide and a direct precursor to nicotinamide adenine dinucleotide. NMN is a key component to proper cell functioning.

Listen to David Sinclair’s multiple explanations on the Joe Rogan Experience Podcast.

Best NMN Delivery Technologies

The strongest NMN in the world doesn’t make a difference if you cannot absorb it Click To Tweet

Before comparing brands and products, you should know one other vital detail that may change your top pick.

The NMN delivery method can change the effects you feel, the potency, the side effect profile, and the price.

	Pure NMN	Sublingual NMN	Intranasal NMN	Liposomal NMN
Absorption	Low	Medium	High	High
Duration	Short	Medium	Short	Up to 24 hours
Onset	Slow	Fastest	Fast	Fast
Dose Required	High	Medium	Low	Low
Target	Muscle	Systemic	Brain	Systemic
Feature	Convenience	Noticeable energy boost	Neuroprotective, relieves brain fog	Extended-release into bloodstream, highest bioavailability
Price	Cheapest	Moderate	Moderate	Expensive
Value	Low	Low	Medium	Best

Normal NMN Powder

Typical NMN powders are the cheapest and the most researched. Most products on the market fall into this category. Unfortunately, it’s also the least absorbed.

Stomach acid degrades unprotected NMN and NR into NAM (nicotinamide) before it can reach the most important tissues. Huge doses of NAD boosters to combat low absorption disproportionately increase NAM. Excess NAM has health consequences, such as inhibiting sirtuins (a vital family of proteins responsible for cellular health and longevity).

Therefore, simply increasing the dose of a typical low-bioavailability NMN powder won’t work well.

Sublingual NMN

Sublingual delivery is NMN dissolved under the tongue. Some companies use special technologies to bypass the liver, rapidly diffusing into the bloodstream, resulting in greater absorption. Usually, it costs more than ordinary powders. Users of sublingual NMN report quickly feeling a big surge of energy and rush.

So far, however, there is little research on exactly how much more bioavailable sublingual powder is compared to oral.

Wondering if your supplements actually do anything or are a waste of money? Feeling the effects of sublingual NMN will convince you.

Intranasal NMN

Intranasal is the latest upcoming NMN delivery method. Only nasal administration can bypass the blood-brain barrier to increase NAD levels in the brain.

Compared to oral use, nasal administration requires far lower doses, has fewer side effects, and has a greater brain impact. Additionally, early research is showing promise in restoring energy post traumatic brain injury.

Due to limited supply, intranasal NMN is also more expensive.

Liposomal NMN

Liposomal supplements absorb faster, more efficiently, and without breaking down in your gut (compared to the typical oral forms). This is true for many supplements. Liposomes also make the NMN sustained release, continuing to increase NAD over a 24-hour period.

Simply put, liposomes are tiny fatty “shells” resembling a human cell membrane. This prevents breakdown by stomach acid and greater use throughout the body. They’ve been used since the 1960s, and some supplement formulators have proclaimed liposomal technology the biggest breakthrough in decades.

Researchers, however, are divided over the difference liposomal technology makes for NMN.

Work by Dr. Christopher Shade suggests liposomes generally increase supplement absorption by 3-10 fold. Giving you better value by requiring a smaller dose. Unfortunately, it’s also the most expensive due to the difficult manufacturing process.

Nicotinamide Mononucleotide (NMN) Benefits

Supplementing the NAD+ molecule itself works, but only in certain bodily systems. NMN, on the other hand, boosts cellular NAD systemically. It restores energy to aging tissues that need it most.

NMN is the hottest compound in longevity research today. It’s of great interest to doctors and health professionals, often discussed by:

• David Sinclair
• Dr. Axe
• Dr. Berg
• Dr. Hyman
• Dr. Rhonda Patrick
• Dr. Peter Attia

Benefits come from both the molecule itself and increasing NAD+ levels. Scientists are still uncovering new health effects daily.

Some of the health benefits of NMN include:

1. Boosts energy metabolism
2. Improves insulin sensitivity
3. Protects against diabetes, fatty liver disease, and obesity
4. Rejuvenates mice
5. Promotes cognition in Alzheimer’s patients
6. Defends against neurodegeneration
7. Improves memory
8. Reduces fat mass
9. Increases lean mass
10. Radically increases NAD+
11. Improve immune function
12. Resistance to microbes and immunodeficiency
13. Better blood flow
14. Confers benefits of calorie restriction
15. Protects the heart
16. Enhancing human performance
17. Re-establishing mobility in the elderly
18. Potentially useful in treating COVID
19. Restores fertility
20. Improves mitochondrial health
21. Greater wellbeing
22. Reduces biological age
23. Promotes DNA repair

Taking nicotinamide mononucleotide helps protect your body and brain. Emerging research finds that NMN optimizes NAD and helps restore organ systems to a healthy state.

But before buying expensive supplements, I suggest going the natural route.

How to Boost NAD Naturally

You can increase NAD levels via two primary ways:

1. Adding: specially formulated boosters
2. Optimizing: the current process (upregulating the salvage pathway)

You’ll get better, longer-lasting results from the latter.

Natural ways to boost your NAD levels without NMN include:

• Raw honey
• Fermented foods
• Sauna sessions
• Pau D’ Arco tea
• Fasting

Eating more of certain foods that contain trace amounts of NMN:

• Broccoli
• Cucumber
• Cabbage
• Avocado
• Tomato
• Edamame

But you won’t get appreciable amounts from these foods alone.

I wrote a mega-guide to naturally boosting your NAD.

After you’ve mastered the simple boosting strategies, you’re ready for the top products.

The Complete Longevity Supplement Stack (NMN & More)

Common NMN Questions and Answers

Top NMN Products to Boost Your NAD Levels

Without adequate NAD, we’d die within seconds.

You’re reading this, so that’s not the issue.

Partially depleted of this cellular “gas”, many of us unknowingly spend our days below our potential.

That’s why many of the world’s top anti-aging and longevity researchers take nicotinamide mononucleotide daily. NMN is arguably the top NAD-boosting supplement available.

Users often report profound energy and overall health changes.

I always recommend starting with the cheap NAD+ boosting precursors.

Certain genes and lifestyle practices, however, can dramatically increase your need for supplementation:

See my review of a powerful tool called SelfDecode I use to understand my genetics and personalize my longevity supplement stack.

Alternatively, you can do an Intracellular NAD test to get a real-time snapshot of your status. Then test again 3-6 months after supplementing. That’s one way to make sure you’re getting the real, unadulterated molecule.

Knowing your underlying biological needs can help you decide whether spending hundreds on NMN will be worth it.

Fake and adulterated products have flooded the NAD supplements scene. Many do not contain any NMN at all. Waste of money aside, using a contaminated NMN product does more harm than good. Choose one of the products above to slow aging, boost energy, and feel your best.

Questions or comments about any of this? Let me know your experience with NAD boosters in the comments below!