Month: April 2024

Key takeaways:~ Dopamine synthesis begins with the conversion of tyrosine to l-DOPA, which is then converted to dopamine.~ The key enzymes in this synthesis are TH (tyrosine hydroxylase) and DDC.~ Genetic variants in these genes, along with lifestyle, diet, and other environmental factors, affect dopamine levels.~ Testing can show you where you’re at, and supplements…

If you follow the latest longevity & biohacking supplement science, you may come across a fascinating molecule called Urolithin A. This trending natural substance stands out as a potential superstar to improve: Mitochondrial function Cognition Skin & beauty Cellular health Longevity Athletic performance Muscle & strength building Gut health Metabolic health Organ system protection Despite…

The MTHFD1 gene encodes the methylenetetrahydrofolate dehydrogenase enzyme, which is an essential part of the folate cycle. It’s a trifunctional enzyme that catalyzes three sequential reactions in the folate cycle, which is essential for DNA synthesis, DNA repair, and DNA methylation. Function of MTHFD1: The MTHFD1 enzyme acts within the folate cycle to convert 5,10-methylenetetrahydrofolate to…

Key takeaways: ~ While the reduced folate carrier (SLC19A1) is the dominant folate receptor throughout the body, two other folate receptors enhance folate uptake in a few specific tissues.~ The folate receptor alpha (FOLR1 gene) is important for the higher folate levels in the cerebrospinal fluid that provide the folate needed in the brain. FOLR2…

Behind closed doors, the world’s elite physical performers use a technology that appears straight out of a sci-fi movie. Getting them results quickly and unattainable via any other means. With low impact, low injury risk, incredible versatility, time efficiency, and much more. It’s called “electric muscle stimulation therapy”. At first blush, this has all the…

Listen to this episode of Longevity by Design on Apple Podcasts, Spotify, and Google Podcasts

Summary: Researchers made a groundbreaking discovery linking environmental contaminants to a reduced span of emotional wellbeing. By utilizing a novel risk assessment tool, the study calculates the loss of happy life expectancy (LHpLE) due to exposure to environmental carcinogens like radon, arsenic, and fine particulate matter, and psychological distress. Surprisingly, cancer’s impact on emotional happiness…

Key takeaways:~ Tick bites can cause some people to make IgE antibodies to galactose-alpha-1,3-galactose (alpha-gal).~ Some people with alpha-gal IgE antibodies have gastrointestinal reactions, hives, or even anaphylaxis a few hours after eating meat.~ The delayed allergic reaction can make it difficult to pinpoint the source of the reaction, leading to misdiagnosis and many frustrating…

Key takeaways:~ Variants in the DPYD gene impact 5-fluorouracil metabolism in cancer patients.~ Knowing your genetics here can give you the “heads up” to talk with your doctor about DPYD variants before cancer treatment. Members will see their genotype report below, plus additional solutions in the Lifehacks section. Consider joining today.  Dihydropyrimidine dehydrogenase deficiency: Dihydropyridine…

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