Bryan Johnson’s Blueprint Protocol with Genetic Links

Acarbose 200 mg (Rx) Acarbose is used to lower blood sugar and it also is being used for longevity research. It is a prescription medication in the US.
An alternative natural option for blood glucose levels is berberine. Diabetes Genetic Risk Report

Blood glucose levels: how your genes impact blood sugar regulation

Guide to Berberine: Research, Benefits, Absorption, and Genetics

Ashwagandha 600 mg While best known for helping with anxiety and stress, many studies show that ashwagandha increases testosterone in men who are working out. Ashwagandha: Researched backed benefits and side effects Astaxanthin 12 mg Astaxanthin is a carotenoid found in shrimp, salmon, lobster, and algae. Skin Aging: Using genomics to solve wrinkles and age spots B Complex .50 pill Mon & Thus (1/2 pill, twice a wk) A low dose of B vitamins fills in any dietary gaps. Some people may need more B12 with aging (older people absorb less B12) or on a vegetarian diet.
The Blueprint diet plan contains lots of natural folate. So for someone not doing the diet part, they may want to check MTHFR and consider their folate consumption.
Be sure to check your COMT variants before supplementing with higher doses of methyl donor supplements. MTHFR: What is it? How to check your data

B12: How do your genes influence your vitamin B12 levels?

Vitamin B6: Genetics, absorption, and deficiency

COMT and Supplement interactions

BroccoMax 17.5mg Broccomax includes a lot of sulforaphane, which is great for upregulating the Nrf2 pathway, which is important for combating toxins in the environment. For men with the GSTM1 null variant, sulforaphane can be important for preventing prostate cancer. Nrf2 pathway: increasing your body’s ability to get rid of toxins

Phthalates: Genes, Detoxification, and Diet

Prostate Problems: Genetic reasons and research on solutions

C 500mg Vitamin C is an antioxidant and water-soluble vitamin. If you aren’t getting enough in your diet, you may want to consider a low dose supplement. Vitamin C: Nutrigenomics, transport, and genetic deficiency Ca-AKG 1 gram Alpha keto-glutarate has some interesting studies on it for longevity. This one may be more beneficial for older individuals. Longevity Lifehacks: AKG for longevity Cocoa Flavanols 500 mg The polyphenols in cocoa may have benefits for heart health.
Note that some people with nickel allergies react to cocoa. Nickel Allergy: Genetics, causes, natural solutions CoQ10 100 mg CoQ10 has lots of solid research on supplementing with it for mitochondrial function, heart health, and brain health. For anyone on a statin, the statin partially blocks the pathway for CoQ10 synthesis. CoQ10 Deficiency and Mitochondrial Energy

Statins and Brain Fog: What is the link?

D-3 2,000 IU Vitamin D is easy to test to see if you need to supplement. People’s needs vary based on sun exposure and genetics. Vitamin D Genes DHEA 25 mg DHEA levels are about 60%  heritable. Some people are likely to benefit more than others from supplementing (age, lifestyle, genes), and there can be drawbacks to going overboard with DHEA. DHEA and Weight E 67 mg Vitamin E is a strong antioxidant. Genetics plays a big role in whether it is likely to be beneficial – or possibly detrimental. Vitamin E: Genetics and Inflammation  EPA 500mg EPA and DHA are essential for the resolution of inflammation, which is an active process that utilizes lipid mediators derived from EPA/DHA. Read the article on specialized pro-resolving mediators. If you don’t get enough fish or seafood in your diet, consider whether a high-quality EPA or DHA supplement may be helpful. Specialized Pro-resolving Mediators: The active process of resolving inflammation Fisetin 200 mg Fisetin is an antioxidant and senolytic. Senolytics can help to clear out senescent cells, which can increase in aging and cause chronic elevations in inflammatory cytokines. Fisetin: Antioxidant and Senolytic Garlic 2.4 g equivalent, Garlic 1.2 g (kyolic) I tend to get a lot of garlic through cooking with it, but there are good studies on garlic for heart health. Genistein 125 mg  Genistein is an isoflavone found in soy beans. It has studies on it that show that it reduces the risk of certain cancers. However, it also may be estrogenic.
Studies on people with high PAI-1 levels (at higher risk of blood clots) show that genistein decreases PAI-1. This is one supplement that may be beneficial in specific cases. Plasminogen Activator Inhibitor-1 (PAI-1): Regulator of clotting

Prostate Problems: Genetic reasons and research on solutions

Ginger Root 2.2 g Ginger is something that I like to get in my diet (because I like ginger…). Studies show that it can inhibit Porphyromonas gingivalis, as well as having antioxidant properties. Advanced glycation end products Glucosamine Sulphate 2KCL 1500 mg Glucosamine is used (usually with chondroitin) for relieving stiffness and joint pain. Osteoarthritis: The Role of Genetics and Natural Solutions Iodine as potassium iodide 125 mcg Keep in mind that this protocol is being used by an individual with hypothyroidism. It may be that not everyone needs more iodine than what they get in their diet. (Check your diet, consider whether you’re using iodized salt.) Thyroid Hormone Levels and Your Genes K2-MK4, 5 mg

K1, 1.5 mg

K2 MK-7  600 mcg

Bone health is essential, and so is keeping calcium from being deposited into the heart or soft tissue. The three forms of vitamin K cover all the bases here. Vitamin K Genes

Genetic influences on osteoporosis and bone health

Lithium 1 mcg 1 mcg of lithium is a very low dose.
Most people get 1 to 3 mg per day of lithium from their diet.
Lithium at low levels (5mg supplements) helps with mood — for some people.
Low doses of lithium (e.g. 0.5mg – 5 mg) are also being studied with the potential for Alzheimer’s prevention.  Lithium and B12: Genetics and mood

Low-dose lithium and Alzheimer’s

Lycopene 10 mg Lycopene is a carotenoid that gives tomatoes (and other vegetables) their red color.  The BCO1 gene encodes the enzyme that converts lycopene, and many people have variants that decrease BCO1. This is something to consider — especially if supplementing with larger doses of lycopene at the same time as consuming beta carotene. BCO1 Gene: Converting Beta-Carotene to Vitamin A Lysine 1 g Lysine is an amino acid found abundantly in meat. For a vegetarian diet, track to see if you need more lysine. Cold Sores: Who gets them and why Melatonin (nighttime only) Melatonin is way more than a ‘sleep hormone’. It is a strong antioxidant that is needed overnight for restoring cellular health. It also is protective against infections and cancer. Your levels of melatonin production decrease with age. Exposure to light at night significantly decreases melatonin production. Melatonin: Key to health and longevity

Melatonin: Immune health

Tryptophan: Kynurenine, Serotonin, and Melatonin

Metformin ER 1,500 mg (Rx) This is a prescription medication in the US for diabetes, but there are some studies on it for longevity. Metformin: Longevity research and genetics Nicotinamide Riboside 375 mg (6 x wk) taken morning and night. This is another supplement that will give more bang for the buck for someone middle-aged or older. Younger individuals still likely produce plenty of NAD+ NAD+ Reversing aging with NMN or NR N-Acetyl-L-Cysteine (NAC) 1,800 mg N-acetylcysteine supplements can help to increase glutathione, which is an antioxidant that your cells produce to combat oxidative stress. Homocysteine Proferrin 10 mg Proferrin is an iron supplement, which could be helpful to anyone who is low in iron. Test first to make sure you need iron. Too much iron is definitely detrimental. Building Up Iron: Hemochromatosis mutations Spermidine 10 mg Spermidine is a biogenic amine that has studies on it for promoting longevity and healthspan. Longevity Lifehacks article: Spermidine and Healthspan Turmeric 1 g Turmeric contains curcumin, which is an antioxidant flavonoid with a lot of good studies on it. Curcumin: Decreasing inflammation Taurine 2 g Taurine promotes bile acids, improves heart health, and acts as an antioxidant. full article on taurine coming next week! Viviscal (male) (female) 1 pill Viviscal is a hair growth supplement with collagen, seaweed, and biotin. Biotin Deficiency: Check your Genes

Will you go bald? Genetics and hair loss

Zeaxanthin (20 mg Lutein, 4 mg Zeaxanthin) 3x/wk Zeaxanthin and lutein are flavonoids used for eye health. Be sure to check for the ARMS2 variant, which is linked to supplements being detrimental instead of helpful, before supplementing with these. Age-Related Macular Degeneration Genes Zinc 15 mg Zinc is essential for so many things. Read the article. 15mg is a standard dose and likely fills in any dietary gaps, especially if you aren’t eating a lot of zinc-rich foods. Zinc genes: The healing power of zinc Rapamycin (Rx) Rapamycin is a mTor inhibitor that is being investigated for longevity. It is currently prescription-only in the US. Rapamycin, mTOR, and Your Genes